Association Between Long-Term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation and Adipokines (Abstract, Kathrin Wolf, Anita Popp, Alexandra Schneider, Susanne Breitner, Regina Hampel, Wolfgang Rathmann, Christian Herder, Michael Roden, Wolfgang Koenig, Christa Meisinger, Annette Peters, KORA-Study Group, Diabetes, Aug. 8, 2016)
Also discussed here: Air pollution a risk factor for diabetes, say researchers (ScienceDaily, Sep.8, 2016)
And here: Diabetes Research - Risk Factor Air Pollution (Press Release, Helmholtz Zentrum München, Sep. 8, 2016)
And here: Air pollution exposure found to be risk factor for type 2 diabetes (Green Car Congress, Sep. 8, 2016)
Today we review research from Germany which examined the level of air pollution at the places of residence of 3,000 participants and how this relates to blood marker levels such as impaled glucose metabolism and the risk of Type 2 diabetes. Results indicate that a 7.9μg/m3 increment in particulate matter <10μm was associated with insulin resistance and that NO2, in particular, had a highly significant effects with pre-diabetic individuals as opposed to those who were either diabetic or not.
“the German Heart Centre analyzed the data of nearly 3,000 participants of the KORA study who live in the city of Augsburg and two adjacent rural counties”
“Exposure to air pollution at the place of residence increases the risk of developing insulin resistance as a pre-diabetic state of type 2 diabetes.”
"The results revealed that people who already have an impaired glucose metabolism, so-called pre-diabetic individuals, are particularly vulnerable to the effects of air pollution…In these individuals, the association between increases in their blood marker levels and increases in air pollutant concentrations is particularly significant! Thus, over the long term -- especially for people with impaired glucose metabolism -- air pollution is a risk factor for type 2 diabetes."
“Among all participants, a 7.9μg/m3 increment in particulate matter <10μm was associated with higher HOMA-IR and insulin”
“Nitrogen dioxide was associated with HOMA-IR, glucose, insulin, and leptin. Effect estimates for pre-diabetic individuals were much larger and highly statistically significant, while non-diabetic and diabetic individuals showed rather weak associations”
"Lowering the threshold for acceptable air pollution levels would be a prudent step…We are all exposed to air pollution. An individual reduction by moving away from highly polluted areas is rarely an option."