Friday, August 5, 2011

Diesel Exhaust Particulates and Heart Disease

Diesel smoke from a big truck.Image via WikipediaCombustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation (12 page pdf, Nicholas L. Mills, Mark R. Miller, Andrew J. Lucking, Jon Beveridge, Laura Flint, A. John F. Boere, Paul H. Fokkens, Nicholas A. Boon, Thomas Sandstrom, Anders Blomberg, Rodger Duffin, Ken Donaldson, PatrickW.F. Hadoke, Flemming R. Cassee, and David E. Newby. European Heart Journal Advance Access, Jul. 13, 2011)

Also discussed here: Diesel Exhaust Increases Heart Attack & Stroke Risk (Citizens for Healthy Development, Jul. 16, 2011)

And here: Bad News: Diesel Particle Emissions Cause Heart Attacks (Gas 2.0, July. 27, 2011)

Today’s review article explores the various gaseous and particulate components of exhaust from diesel motors in terms of vascular response and test various filters used to reduce health impacts.

Key Quotes:

“These associations are strongest for fine particulate matter (PM2.5) air pollution that arises from a variety of sources, including the combustion of diesel fuel by automobiles.. thought to explain the association between transient exposure to road traffic and the triggering of acute myocardial infarction”

“our present study was designed specifically to determine the role of nanoparticulate emissions, and whether the organic and inorganic surface compounds, or the carbonaceous particles themselves, are the main arbiter of the adverse cardiovascular effects”

“These particles can be filtered out of exhaust emissions through the use of particle …but these filters require consistent, expensive maintenance.”

“Experimental studies have established that diesel exhaust particles induce cellular oxidative stress and up-regulate pro-inflammatory pathways. Particle size, surface area, and surface chemistry are thought to be important determinants of these cellular effects”

“Our research shows that while both gases and particles can affect our blood pressure, it is actually the miniscule chemical particles … that are really harmful. These particles produce highly reactive molecules called free radicals that can injure our blood vessels and lead to vascular disease, … in the future we can try and remove these chemicals, and prevent the health effects of vehicle emissions.”

““people with (existing) heart disease should avoid spending long periods outside or in areas where traffic pollution is likely to be high … or near busy roads.”
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