Tuesday, May 17, 2016

How is Air Pollution Linked to Diabetes and Insulin Sensitivity?

English: idealized curves of human blood gluco...
English: idealized curves of human blood glucose and insulin concentrations during the course of a day containing three meals; in addition, effect of sugar-rich meal is highlighted; (Photo credit: Wikipedia)
Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans (Abstract, Zhanghua Chen, Muhammad T. Salam, Claudia Toledo-Corral, Richard M. Watanabe, Anny H. Xiang, Thomas A. Buchanan, Rima Habre, Theresa M. Bastain, Fred Lurmann, John P. Wilson, Enrique Trigo and Frank D. Gilliland, Diabetes Care, Mar.29, 2016)

Today we review research conducted in Mexico that examined the links between air pollution and insulin sensitivity. Results indicated that short term (under 2 months) exposure to fine particulates (PM2.5) was linked to lower insulin sensitivity and higher cholesterol and this effect was highest with obese patients.  

 Key Quotes:

“Ambient air pollutant concentrations (NO2, O3, and PM2.5) for short- and long-term periods were assigned by spatial interpolation (maximum interpolation radius of 50 km) of data from air quality monitors. Traffic-related air pollution from freeways (TRAP) was estimated using the dispersion model as NOx”  

Short-term (up to 58 days cumulative lagged averages) exposure to PM2.5 was associated with lower insulin sensitivity and HDL-to-LDL cholesterol ratio and higher fasting glucose and insulin, HOMA-IR, total cholesterol, and LDL cholesterol (LDL-C)”

“The effects of short-term PM2.5 exposure on insulin sensitivity were largest among obese participants.” “Exposure to ambient air pollutants adversely affects glucose tolerance, insulin sensitivity, and blood lipid concentrations.”

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