|A sketch displaying the efflux transports at the blood-brain barrier. Inspired by a sketch from S. Ohtsuki: New aspects of the blood-brain barrier transporters; its physiological roles in the central nervous system. In: Biol Pharm Bull. 27, 2004, pp. 1489-1496. PMID 15467183 (Photo credit: Wikipedia)|
Air Pollution and Children: Neural and Tight Junction Antibodies and Combustion Metals, the Role of Barrier Breakdown and Brain Immunity in Neurodegeneration (Abstract, Lilian Calderón-Garcidueñas, Aristo Vojdani, Eleonore Blaurock-Busch, Yvette Busch, Albrecht Friedle, Maricela Franco-Lira, Partha Sarathi-Mukherjee, Su-Bin Park, Ricardo Torres-Jardón, Amedeo D'Angiulli, Journal of Alzheimer’s Disease, Aug. 2014)
Also discussed here: Air pollution harmful to young brains, study finds (ScienceDaily, 10 Sep. 10, 2014) And here: Air Pollution Invades Kids' Brain Barriers, May Cause Neurological Diseases (Anthony Rivas, Medical Daily, Sep. 10, 2014
Today we review research that found that fine particulate air pollutants (typical in exhausts of diesel buses and trucks) can penetrate barriers in the lungs, intestines and brain that, in turn, can affect children’s health and lead to long term permanent damage, including the onset of Alzheimer’s Disease, Parkinson’s Disease or multiple sclerosis.
“The study found when air particulate matter and their components such as metals are inhaled or swallowed, they pass through damaged barriers, including respiratory, gastrointestinal and the blood-brain barriers and can result in long-lasting harmful effects.”
"We asked why a clinically healthy kid is making autoantibodies against their own brain components….That is indicative of damage to barriers that keep antigens and neurotoxins away from the brain. Brain autoantibodies are one of the features in the brains of people who have neuroinflammatory diseases like multiple sclerosis."
"The barriers are there for a reason…They are there to protect you, but once they are broken the expected results are not good."
“Air pollution exposure damages epithelial and endothelial barriers and is a robust trigger of tight junction and neural antibodies.”
“The major factor determining the impact of neural antibodies is the integrity of the blood-brain barrier. Defining the air pollution linkage of the brain/immune system interactions and damage to physical and immunological barriers with short and long term neural detrimental effects to children's brains ought to be of pressing importance for public health.”