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| English: Ozone molecular electrical potential surface 3D-vdW (Photo credit: Wikipedia) |
Controlled Exposure of Healthy Young Volunteers to Ozone Causes Cardiovascular Effects (27 page pdf, Robert B. Devlin, Kelly E. Duncan, Melanie Jardim, Michael T. Schmitt, Ana G. Rappold, and David Diaz-Sanchez, Circulation, Jun. 25, 2012)
Also discussed here: Ozone Exposure Linked to Potential Heart Attacks (ScienceDaily, Jun. 25, 2012)
And here: New evidence links ozone exposure to potential heart attacks (American Heart Association, Jun. 25, 2012)
Today we review research into the link between exposure to ozone for a few hours and the impacts on the cardiovascular system, as well as the pathway to explain these impacts. Results indicate a clear link that adds to the complexity of assessing impact on heart disease from air pollution, previously thought to be mainly from fine particulate matter.
Key Quotes:
“Twenty three young healthy individuals were exposed in a randomized crossover fashion to clean air and 0.3 ppm ozone for two hours while undergoing intermittent exercise.”
“Ground level ozone is created when pollutants from vehicles, power plants, industry, chemical solvents and consumer products react in the presence of sunlight”
“This controlled human exposure study shows that ozone can cause an increase in vascular markers of inflammation, changes in markers of fibrinolysis, as well markers that affect autonomic control of heart rate and repolarization”
“the changes in ozone-induced vascular inflammation, fibrinolysis markers and heart rate variability (HRV) V detailed in this study provides the most compelling data to date of the potential for ozone to modulate the cardiovascular system”
“we observed robust changes in several pro-inflammatory cytokines in the blood within an hour after exposure to ozone”
“Given the reactivity of ozone, if it were to diffuse into the circulatory system the concentration in arteries would likely be higher then in veins, raising the intriguing possibility that if small quantities of ozone were to diffuse into the blood they might contribute to oxidation of cholesterol found in the plaques”
“This study provides a plausible explanation for the link between acute ozone exposure and death”
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